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KMID : 0380020070220060393
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Korean Journal of Biotechnology and Bioengineering
2007 Volume.22 No. 6 p.393 ~ p.400
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Applications and Developmental Prospect of Protein Microarray Technology
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Abstract
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Analysis of protein interactions/functions in a microarray format has been of great potential in drug discovery, diagnostics, and cell biology, because it is amenable to large-scale and high-throughput biological assays in a rapid and economical way. In recent years, the protein microarray have broaden their utility towards the global analysis of protein interactions on a proteome scale, the functional activity analysis based on protein interactions and post-translational modifications (PTMs), and the discovery of biomarkers through profiling of protein expression between sample and reference pool. As a promising tool for proteomics, the protein microarray technology has advanced outstandingly over the past decade in terms of surface chemistry, acquisition of relevant proteins on a proteomic level, and detection methods. In this article, we briefly describe various techniques for development of protein microarray, and introduce developmental state of protein microarray and its applications.
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KEYWORD
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Protein microarray, biochip, high-throughput system
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